The Secret Life of Smad4
نویسنده
چکیده
Smad4 is an important mediator of signaling by TGFbeta family members that is presumed to be controlled by the phosphorylation status of its partners, the receptor-regulated R-Smads. In this issue, Dupont et al. (2009) now reveal that Smad4 itself is subject to cycles of ubiquitination and deubiquitination that regulate its interactions with the R-Smads.
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ورودعنوان ژورنال:
- Cell
دوره 136 شماره
صفحات -
تاریخ انتشار 2009